POS0486 FACTORS ASSOCIATED WITH CHRONOTROPIC RESPONSE IN PEOPLE WITH RHEUMATOID ARTHRITIS

Background: People with rheumatoid arthritis (RA) are at high risk for cardiovascular diseases (CVD) and CVD mortality. Reduced Chronotropic response (CR), which produces exercise intolerance, is known as a contributing factor to Studies have shown that people RA reduced CR. However, knowledge about the factors associated CR in limited. Objectives: To explore including factors, inflammatory markers cardiorespiratory fitness (VO 2 peak). Methods: 106 completed treadmill tolerance test while heart rate (HR) was monitored via 12 leads ECG. defined percentage of [(achieved peak HR minus resting HR) divided by (age-predicted maximum HR)]. Serological lipids profile, insulin resistance sensitivity (HOMA, QUICKi), C-reactive protein (hsCRP), erythrocyte sedimentation (ESR), fibrinogen white blood cells (WBC) were examined fasted sample. VO assessed breath-by-breath gas analysis. Results: 34% had based on cut-off value (≤ 80%) average 86.2 ± 21%. Body mass index (r=-0.33, p=.001), HOMA (r=-0.26, p=.009), hsCRP (r=-0.23, p=.02), ESR (r=-0.21, p=.04), (r=-0.2, p=.05), WBC p=.04) inversely CR, whereas, density lipoprotein (HDL) (r=0.43, p<.001), QUICKi (r=0.31, p=.002), (r=0.4, p<.001) positively When all variables entered into stepwise linear regression, HDL (p<.001) (p=.009) independently Conclusion: The current findings suggest many markers, fitness. Among varibales, moderately Future studies should investigate effect improving these training programes. Acknowledgements: Thanks physical activity Rheumatoid research team Research department Dudley Hospital. Sincere appreciation gratitude Dr Jet Veldhuizen van Zanten, Prof. Joan Duda, George Kitas from University Birmingham Metsios Wolverhampton. Disclosure Interests: None declared